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Diazepam should not be used by individuals with:

Myasthenia gravis – Diazepam can worsen muscle weakness in people with this neuromuscular disease.

Severe liver disease – Diazepam is metabolized by the liver, so liver impairment can increase side effects and toxicity.

Respiratory problems – Diazepam depresses respiration so should be avoided in people with breathing difficulties like COPD or sleep apnea.

Pregnancy and breastfeeding – Diazepam crosses the placenta and is excreted in breast milk, so should be avoided unless the benefits outweigh the risks.

Depression, suicidal ideation – Diazepam can worsen depression and increase suicidal thoughts and behavior.

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